<rdf:RDF
    xmlns:vitro-public="http://vitro.mannlib.cornell.edu/ns/vitro/public#"
    xmlns:c4o="http://purl.org/spar/c4o/"
    xmlns:ero="http://purl.obolibrary.org/obo/"
    xmlns:pvs="http://vivoweb.org/ontology/provenance-support#"
    xmlns:owl2="http://www.w3.org/2006/12/owl2-xml#"
    xmlns:scirr="http://vivoweb.org/ontology/scientific-research-resource#"
    xmlns:vivo="http://vivoweb.org/ontology/core#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:afn="http://jena.apache.org/ARQ/function#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:scires="http://vivoweb.org/ontology/scientific-research#"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
    xmlns:geo="http://aims.fao.org/aos/geopolitical.owl#"
    xmlns:skco="http://www.w3.org/2004/02/skos/core#"
    xmlns:event="http://purl.org/NET/c4dm/event.owl#"
    xmlns:dcelem="http://purl.org/dc/elements/1.1/"
    xmlns:vitro="http://vitro.mannlib.cornell.edu/ns/vitro/0.7#"
    xmlns:vann="http://purl.org/vocab/vann/"
    xmlns:skos="http://www.w3.org/2008/05/skos#"
    xmlns:swvs="http://www.w3.org/2003/06/sw-vocab-status/ns#"
    xmlns:owl="http://www.w3.org/2002/07/owl#"
    xmlns:fabio="http://purl.org/spar/fabio/"
    xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#">
  <owl:Ontology rdf:about="http://vivoweb.org/ontology/scientific-research"/>
  <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/">
    <vitro:ontologyPrefixAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >ero</vitro:ontologyPrefixAnnot>
  </owl:Ontology>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000394">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A service that produces a physical object or data, such as a custom micro-array chip, a made to order antibody, or a behavioral dataset</vitro:descriptionAnnot>
    <rdfs:subClassOf rdf:resource="http://vivoweb.org/ontology/core#Service"/>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A service that produces a physical object or data.</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000006">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >eagle-i: Material entity that is used in a chemical reaction or other experimental process to detect, measure, examine, or produce other  substances.
NOTE: For now we are not addressing whether this is a subclass of foaf:Agent</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Material entity that is used in a chemical reaction or other experimental process to detect, measure, examine, or produce other  substances.</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://vivoweb.org/ontology/scientific-research#Phase1ClinicalTrial">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >In Phase I trials, researchers test an experimental drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Phase 1 Clinical Trial</vitro:shortDef>
    <rdfs:subClassOf>
      <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000016"/>
    </rdfs:subClassOf>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100026">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >OBI: An organism is material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
NOTE that we are not addressing for now the issue of whether a foaf:Person is a subclass of obi:Organism</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >An organism is a material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment.</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000016">
    <rdfs:subClassOf>
      <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000015"/>
    </rdfs:subClassOf>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A clinical trial is a research study using human volunteers to answer questions about treatments for diseases and conditions. Clinical trials are conducted in phases. The trials at each phase have a different purpose and help scientists answer different questions.</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A research study using human volunteers to answer specifc health-related questions. </vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000020">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >eagle-i: Material entity that is a portion or quantity of a biological material for use in testing, examination, or study.  A biological specimen can be an individual animal, part of or derived an animal, plant, part of a plant, or microorganism. When a taxon is described, it is typically based on a single specimen and is referred to as the holotype.</vitro:descriptionAnnot>
    <vitro:exampleAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >An individual animal, part of or derived an animal, plant, part of a plant, or microorganism.</vitro:exampleAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A portion or quantity of a biological material for use in testing, examination, or study.</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://vivoweb.org/ontology/scientific-research#Phase3ClinicalTrial">
    <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000016"/>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >In Phase 3 trials, an experimental study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the experimental drug or treatment to be used safely.
</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Phase 3 Clinical Trial</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000004">
    <rdfs:subClassOf>
      <owl:Restriction>
        <owl:onProperty>
          <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/ERO_0000460"/>
        </owl:onProperty>
        <owl:allValuesFrom rdf:resource="http://purl.org/ontology/bibo/Document"/>
      </owl:Restriction>
    </rdfs:subClassOf>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >An implement used to facilitate work, especially precision work.</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >An implement used to facilitate work, especially precision work.</vitro:shortDef>
    <rdfs:subClassOf rdf:resource="http://vivoweb.org/ontology/core#Equipment"/>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000272">
    <rdfs:subClassOf rdf:resource="http://purl.org/ontology/bibo/Document"/>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A protocol is a plan specification which has sufficient level of detail and quantitative information to communicate it between domain experts, so that different domain experts will reliably be able to independently reproduce the process.</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A plan specification that allows different domain experts to reliably and independently reproduce a process.</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://vivoweb.org/ontology/scientific-research#Phase0ClinicalTrial">
    <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000016"/>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Phase 0 is a recent designation for exploratory, first-in-human trials  conducted in accordance with the United States Food and Drug Administration's (FDA) 2006 Guidance on Exploratory Investigational New Drug (IND) Studies.  Phase 0 trials are also known as human microdosing  studies and are designed to speed up the development of promising drugs or imaging agents by establishing very early on whether the drug or agent behaves in human subjects as was expected from preclinical studies.</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Phase 0 Clinical Trial</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://vivoweb.org/ontology/scientific-research#Phase4ClinicalTrial">
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Phase 4 Clinical Trial</vitro:shortDef>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >In Phase 4 trials, post marketing studies delineate additional information including the drug's or treatment's risks, benefits, and optimal use.</vitro:descriptionAnnot>
    <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000016"/>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000391">
    <rdfs:subClassOf rdf:resource="http://vivoweb.org/ontology/core#Service"/>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A service in which a service consumer receives the right to use a resource (instrument, database, software, etc) that is owned or managed by a service provider.  Ownership of the accessed resource remains with the service provider during and after provision of service.</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A service in which a service consumer receives the right to use a resource (instrument, database, software, etc) that is owned or managed by a service provider.  Ownership of the accessed resource remains with the service provider during and after provisi</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000014">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >The comment in ero says  "Maybe sameAs Investigation but is subject of funding"</vitro:descriptionAnnot>
    <rdfs:subClassOf rdf:resource="http://vivoweb.org/ontology/core#Project"/>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A project whose goal is the increase of knowledge, the primary aim being a greater knowledge or understanding of the subject under study.</vitro:shortDef>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000015">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >eagle-i: Research project that uses or collects measurements or assessments about humans.</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Research project that uses or collects measurements or assessments about humans.</vitro:shortDef>
    <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000014"/>
  </owl:Class>
  <owl:Class rdf:about="http://vivoweb.org/ontology/scientific-research#Phase2ClinicalTrial">
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Phase 2 Clinical Trial</vitro:shortDef>
    <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000016"/>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >In Phase 2 trials, an experimental study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.</vitro:descriptionAnnot>
  </owl:Class>
  <owl:Class rdf:about="http://purl.obolibrary.org/obo/ERO_0000392">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A service in which a service consumer provides some material or data as input which a service provider stores and returns as output.</vitro:descriptionAnnot>
    <vitro:shortDef rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >A service in which a service consumer provides some material or data as input which a service provider stores and returns as output.</vitro:shortDef>
    <rdfs:subClassOf rdf:resource="http://vivoweb.org/ontology/core#Service"/>
  </owl:Class>
  <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/ERO_0000029">
    <owl:inverseOf>
      <owl:ObjectProperty rdf:about="http://vivoweb.org/ontology/scientific-research#accessProvidedBy"/>
    </owl:inverseOf>
    <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/ERO_0000391"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/ERO_0000460">
    <owl:inverseOf>
      <owl:ObjectProperty rdf:about="http://vivoweb.org/ontology/scientific-research#documentationFor"/>
    </owl:inverseOf>
    <rdfs:range rdf:resource="http://purl.org/ontology/bibo/Document"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/ERO_0000481">
    <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0000272"/>
    <owl:inverseOf>
      <owl:ObjectProperty rdf:about="http://vivoweb.org/ontology/scientific-research#protocolRealizedBy"/>
    </owl:inverseOf>
    <rdfs:domain rdf:resource="http://vivoweb.org/ontology/core#Service"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:about="http://vivoweb.org/ontology/scientific-research#documentationFor">
    <rdfs:domain rdf:resource="http://purl.org/ontology/bibo/Document"/>
    <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000460"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:about="http://vivoweb.org/ontology/scientific-research#accessProvidedBy">
    <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/ERO_0000391"/>
    <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000029"/>
  </owl:ObjectProperty>
  <owl:ObjectProperty rdf:about="http://vivoweb.org/ontology/scientific-research#protocolRealizedBy">
    <rdfs:range rdf:resource="http://vivoweb.org/ontology/core#Service"/>
    <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/ERO_0000481"/>
    <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0000272"/>
  </owl:ObjectProperty>
  <owl:DatatypeProperty rdf:about="http://vivoweb.org/ontology/scientific-research#irbNumber">
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >Every clinical trial in the United States must be approved and monitored by an Institutional Review Board (IRB). An IRB is an independent committee of physicians, statisticians, community advocates and others whose objective is to ensure that a clinical trial is ethical and the rights of study participants are protected. </vitro:descriptionAnnot>
    <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/ERO_0000016"/>
  </owl:DatatypeProperty>
  <owl:DatatypeProperty rdf:about="http://vivoweb.org/ontology/scientific-research#studyPopulationCount">
    <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/ERO_0000016"/>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >number of human participants in the study (trial).</vitro:descriptionAnnot>
  </owl:DatatypeProperty>
  <owl:DatatypeProperty rdf:about="http://vivoweb.org/ontology/scientific-research#nctId">
    <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/ERO_0000016"/>
    <vitro:descriptionAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >ClinicalTrials.gov is an ICMJE-acceptable public registry, offering up-to-date information for locating clinical trials for a wide range of diseases and conditions. The U.S. National Institutes of Health (NIH), through its National Library of Medicine (NLM), developed this site in collaboration with the Food and Drug Administration (FDA), as a result of the FDA Modernization Act, which was passed into law in November 1997.   This property should be publically visible since it is one of the principal identifiers in a national registry of clinical trials </vitro:descriptionAnnot>
    <vitro:exampleAnnot rdf:datatype="http://www.w3.org/2001/XMLSchema#string"
    >NCT00000419</vitro:exampleAnnot>
    <rdfs:subPropertyOf rdf:resource="http://vivoweb.org/ontology/core#identifier"/>
  </owl:DatatypeProperty>
</rdf:RDF>
